Beilstein J. Org. Chem.2021,17, 749–761, doi:10.3762/bjoc.17.65
transfection reagent, whereas, N+ONs remain concentrated in vesicles within the cytoplasm. These results indicate that both N+ and Ts-modified ONs are promising for various in vivo applications.
Keywords: cell uptake; charge neutral modification; DNA; modifiedphosphates; Staudinger reaction; Introduction
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Graphical Abstract
Figure 1:
Illustration of H-bonding in a DNA duplex and a parallel triplex. A) Depiction of Watson–Crick base...